Calculated LDL cholesterol concentration

Select the unit system. Enter CHOL, HDLn, and TRIG values.

Patient information

Patient name

Date of analysis

Input units

Conventional units SI units

CHOL mg/dL

HDLn mg/dL

TRIG mg/dL

Calculated LDL cholesterol concentration

According to the modified Sampson

— mg/dL

Please verify the entered values. One or more values are outside the usual working range.

Please enter valid non-negative numbers for CHOL, HDLn, and TRIG.

Background information

This calculator estimates LDL cholesterol concentration using Modified Sampson equations for either conventional units (mg/dL) or SI units (mmol/L).

The calculated LDL cholesterol value should always be interpreted together with the patient’s clinical condition and other lipid profile results.

Conventional units:
LDL cholesterol co = CHOL − HDLn − TRIG/8.37 − TRIG × (CHOL − HDLn)/2640 + TRIG²/17400

SI units:
LDL cholesterol si = CHOL − HDLn − TRIG/3.65 − TRIG × (CHOL − HDLn)/29.81 + TRIG²/85.77

Note:
This formula is only compatible with the HDLn method using the HBL0110 reagent kit.

Reference:
Sampson M, Zubiran R, Wolska A, et al. A Modified Sampson–NIH Equation with Improved Accuracy for Estimating Low Levels of Low-Density Lipoprotein-Cholesterol. Clinical Chemistry. 2025;71(11):1125-1137. doi:10.1093/clinchem/hvaf073.