If you are measuring LDL-Cholesterol or using the Friedewald equation, this article is relevant to you as it proposes a better alternative: the modified Sampson equation.

The modified Sampson equation uses the classic lipid panel inputs (Total Cholesterol, HDL-Cholesterol, and Triglycerides) but delivers better results for patients with LDL-Cholesterol below 70 mg/dL.

Check the article and consider calculating LDL-Cholesterol values in your lab.

(Source: Sampson M, Zubiran R, Wolska A, et al. A Modified Sampson–NIH Equation with Improved Accuracy for Estimating Low Levels of Low-Density Lipoprotein-Cholesterol. Clinical Chemistry. 2025;00(0):1–13. doi:10.1093/clinchem/hvaf073.)